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Streptococcus sanguinis Class Ib Ribonucleotide Reductase

1 Jan 2014

Abstract excerpt

Streptococcus sanguinis is a causative agent of infective endocarditis. Deletion of SsaB, a manganese transporter, drastically reduces S. sanguinis virulence. Many pathogenic organisms require class Ib ribonucleotide reductase (RNR) to catalyze the conversion of nucleotides to deoxynucleotides under aerobic conditions, and recent studies demonstrate that this enzyme uses a dimanganese-tyrosyl radical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24381172
DOI: 10.1074/jbc.m113.533554

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