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Article

A comprehensive framework for trans-ancestry pathway analysis using GWAS summary data from diverse populations.

PLoS genetics - 1 Oct 2024

Fu Sheng, Wheeler William, Wang Xiaoyu, Hua Xing, Godbole Devika, Duan Jubao, Zhu Bin, Deng Lu, Qin Fei, Zhang Haoyu, Shi Jianxin, Yu Kai

Abstract excerpt

As more multi-ancestry GWAS summary data become available, we have developed a comprehensive trans-ancestry pathway analysis framework that effectively utilizes this diverse genetic information. Within this framework, we evaluated various strategies for integrating genetic data at different levels-SNP, gene, and pathway-from multiple ancestry groups. Through extensive simulation studies, we have identified robust...

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Identifiers

PMID: 39441834
DOI: 10.1371/journal.pgen.1011322
PMCID: PMC11534268

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