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Article

Genetic analysis of psychosis Biotypes: shared Ancestry-adjusted polygenic risk and unique genomic associations.

Molecular psychiatry - 1 Jun 2025

Xia Cuihua, Alliey-Rodriguez Ney, Tamminga Carol A, Keshavan Matcheri S, Pearlson Godfrey D, Keedy Sarah K, Clementz Brett, McDowell Jennifer E, Parker David, Lencer Rebekka, Hill S Kristian, Bishop Jeffrey R, Ivleva Elena I, Wen Cindy, Dai Rujia, Chen Chao, Liu Chunyu, Gershon Elliot S

Abstract excerpt

The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) created psychosis Biotypes based on neurobiological measurements in a multi-ancestry sample. These Biotypes cut across DSM diagnoses of schizophrenia, schizoaffective disorder, and bipolar disorder with psychosis. Two recently developed post hoc ancestry adjustment methods of Polygenic Risk Scores (PRSs) generate Ancestry-Adjusted PRSs...

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Bipolar Disorder
Brain
Genomics
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multifactorial Inheritance

Psychotic Disorders

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Open in PubMed Open full text

Identifiers

PMID: 39709506
DOI: 10.1038/s41380-024-02876-z
PMCID: PMC12092190

Genes

ARTN
CYREN
NCAM1
RET
TMEM140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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