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Article

Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis.

Molecular psychiatry - 1 Aug 2024

Warren Tracy L, Tubbs Justin D, Lesh Tyler A, Corona Mylena B, Pakzad Sarvenaz S, Albuquerque Marina D, Singh Praveena, Zarubin Vanessa, Morse Sarah J, Sham Pak Chung, Carter Cameron S, Nord Alex S

Abstract excerpt

A primary goal of psychiatry is to better understand the pathways that link genetic risk to psychiatric symptoms. Here, we tested association of diagnosis and endophenotypes with overall and neurotransmitter pathway-specific polygenic risk in patients with early-stage psychosis. Subjects included 205 demographically diverse cases with a psychotic disorder who underwent comprehensive psychiatric and neurological...

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Identifiers

PMID: 38491343
DOI: 10.1038/s41380-024-02457-0
PMCID: PMC11412910

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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