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Cross-ancestry genetic architecture reveals shared biological pathways of major psychiatric disorders.

Molecular psychiatry - 1 Jul 2026

Feng Yu, Jia Ningning, Huang Peng, Hu Shaohua, Yang Sheng

Abstract excerpt

Psychiatric disorders, including bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SCZ), share substantial genetic overlap. We conducted a cross-ancestry multivariate genome-wide association study (GWAS) integrating European and East Asian populations to uncover shared genetic underpinnings. Our analyses identified 403 loci associated with shared polygenic liability to psychiatric...

Topics

Humans
Bipolar Disorder
Brain
East Asian People
European People
Genetic Risk Score
Genome-Wide Association Study
Major Depressive Disorder
Mental Disorders
Multifactorial Inheritance
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Schizophrenia

Signal Transduction

White People

Source

Identifiers

PMID: 41844800
DOI: 10.1038/s41380-026-03541-3

Genes

NEGR1
FGFR1
NCAM1
VRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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