Hepatic Zonation in MASLD: Old Question, New Challenge in the Era of Spatial Omics

Abstract excerpt

Hepatic zonation reflects the concept that hepatocytes and nonparenchymal cells (NPCs) perform distinct metabolic functions, depending on their spatial localization along the porto-central axis. The maintenance of this fine-tuned organization is essential for liver homeostasis, and its disruption may contribute to liver diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). Fat...

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