Article

Circadian Dysregulation in Aging Alters Senescence and Inflammatory Pathways in a Sex- and Time-of-Day–Dependent Manner

2026-03-08

Abstract excerpt

The circadian rhythm orchestrates gene expression and critical physiological processes but becomes disrupted with aging, contributing to disease. How this disruption interacts with cellular senescence—a key driver of aging pathology—remains poorly defined. We studied renal gene expression at four timepoints over 24hrs in 6- and 24-month-old genetically diverse UM-HET3 mice of both sexes and performed complementary...

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Literature Corpus work: 083bfc25-eba9-5ec1-8253-bbb9182adf52
DOI: 10.64898/2026.03.05.709919

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