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Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseases

2 Sept 2021

Abstract excerpt

INTRODUCTION: New insights indicate a causative link between cellular senescence and liver fibrosis. Senescent hepatic stellate cells (HSCs) facilitate fibrosis resolution, while senescence in hepatocytes and cholangiocytes acts as a potent mechanism driving liver fibrogenesis. In many clinical studies, telomeres and mitochondrial DNA contents, which are both aging biomarkers, were reportedly associated with a...

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PMID: 34632912
DOI: 10.1080/14728222.2021.1992385

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