Article

Spatial Transcriptomic Signature of Progressive Fibrosis in Human MASLD: Role of Senescence and Metabolic Reprogramming

2025-03-22

Abstract excerpt

Granular detail about the location and nature of liver cell interactions and the metabolic, inflammatory and fibrogenic pathways driving progressive fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD) is needed to deliver novel therapeutic targets. Here we used spatial transcriptomic data from human MASLD liver biopsies to identify the major cell types and their potential interconnected ac...

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Literature Corpus work: 37631dd9-5fb9-5ef6-9467-6c872f67ce3f
DOI: 10.1101/2025.03.20.644239

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