Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aging disrupts hepatocyte zonation homeostasis in mice and humans

4 Jul 2025

Abstract excerpt

BACKGROUND AND AIMS: Aging-induced degenerative changes in the liver are not inherently pathologic but pose an increased risk for liver diseases. However, the molecular mechanisms underlying aging-induced hepatic dyshomeostasis remain incompletely characterized. Here, we investigate how aging alters liver architecture, cellular communication, and hepatocyte zonation. APPROACH AND RESULTS: Histological analyses of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Liver physiology and pathology
Share to Organ Transplantation Techniques and Outcomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40622856
DOI: 10.1097/hep.0000000000001451

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aging disrupts hepatocyte zonation homeostasis in mice and humansPMID 40622856Read ↗

Cellular senescence is associated with age-related loss of liver zonation and hepatocyte functionSemantic proximity Read ↗

Single‐cell transcriptome analysis of aging mouse liverSemantic proximity Read ↗

Liver zonation, revisitedSemantic proximity Read ↗

Liver Zonation Disruption Fuels Hepatocellular Carcinoma in Chronic Liver DiseaseSemantic proximity Read ↗

Single-cell omics analysis reveals functional diversification of hepatocytes during liver regenerationSemantic proximity Read ↗

Dysregulation of murine long non-coding single cell transcriptome in non-alcoholic steatohepatitis and liver fibrosisSemantic proximity Read ↗

Temporal Analyses of Postnatal Liver Development and Maturation by Single Cell TranscriptomicsSemantic proximity Read ↗

Single-cell transcriptomics reveals the impact of sex and age in the healthy human liverSemantic proximity Read ↗

An Integrated Single-Cell Atlas Reveals Hepatic Stellate Cell Heterogeneity and Spatiotemporal Dynamics after Liver InjurySemantic proximity Read ↗

Decoding liver fibrogenesis with single-cell technologiesSemantic proximity Read ↗

Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert MastersSemantic proximity Read ↗

Spatio-Temporal Multiscale Analysis of Western Diet-Fed Mice Reveals a Translationally Relevant Sequence of Events during NAFLD ProgressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.