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Article

Phenotypes and ontogeny of senescent hepatic stellate cells in metabolic dysfunction-associated steatohepatitis.

Journal of hepatology - 1 Aug 2024

Yashaswini Chittampalli N, Qin Tianyue, Bhattacharya Dipankar, Amor Corina, Lowe Scott, Lujambio Amaia, Wang Shuang, Friedman Scott L

Abstract excerpt

BACKGROUND & AIMS: Hepatic stellate cells (HSCs) are the key drivers of fibrosis in metabolic dysfunction-associated steatohepatitis (MASH), the fastest growing cause of hepatocellular carcinoma (HCC) worldwide. HSCs are heterogenous, and a senescent subset of HSCs is implicated in hepatic fibrosis and HCC. Administration of anti-uPAR (urokinase-type plasminogen activator receptor) CAR T cells has been shown to...

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PMID: 38508241
DOI: 10.1016/j.jhep.2024.03.014
PMCID: PMC11269047

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