Identifying specific functional roles for senescence across cell types

Abstract excerpt

Summary Cellular senescence plays critical roles in aging, regeneration, and disease; yet, the ability to discern its contributions across various cell types to these biological processes remains limited. In this study, we generated an in vivo genetic toolbox consisting of three p16Ink4a-related intersectional genetic systems, enabling pulse-chase tracing (Sn-pTracer), Cre-based tracing and ablation (Sn-cTracer),...

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• Share to Circadian rhythm and melatonin
• Share to Genetics, Aging, and Longevity in Model Organisms
• Share to Telomeres, Telomerase, and Senescence