Article

Polycomb Epigenetic Programs Contribute to Tic Disorder Pathophysiology Independently of Antipsychotic Drug Targets

2026-08-19

Abstract excerpt

<title>Abstract</title> <p>Tic disorders are developmental neuropsychiatric conditions in which involuntary motor and vocal tics are thought to arise from abnormal cortico-striato-thalamo-cortical and related cerebellar-thalamo-cortical circuit function. Current treatments, especially dopamine-modulating antipsychotics, can reduce tic severity but are often limited by incomplete response, adverse effects, and unc...

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Literature Corpus work: ffc6f760-517b-54d6-8c4f-260456c0c22e
DOI: 10.21203/rs.3.rs-10385466/v1

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