Article
Genome-Wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome.
Biological psychiatry - 15 Jul 2024
Tsetsos Fotis, Topaloudi Apostolia, Jain Pritesh, Yang Zhiyu, Yu Dongmei, Kolovos Petros, Tumer Zeynep, Rizzo Renata, Hartmann Andreas, Depienne Christel, Worbe Yulia, Müller-Vahl Kirsten R, Cath Danielle C, Boomsma Dorret I, Wolanczyk Tomasz, Zekanowski Cezary, Barta Csaba, Nemoda Zsofia, Tarnok Zsanett, Padmanabhuni Shanmukha S, Buxbaum Joseph D, Grice Dorothy, Glennon Jeffrey, Stefansson Hreinn, Hengerer Bastian, Yannaki Evangelia, Stamatoyannopoulos John A, Benaroya-Milshtein Noa, Cardona Francesco, Hedderly Tammy, Heyman Isobel, Huyser Chaim, Mir Pablo, Morer Astrid, Mueller Norbert, Munchau Alexander, Plessen Kerstin J, Porcelli Cesare, Roessner Veit, Walitza Susanne, Schrag Anette, Martino Davide, Tischfield Jay A, Heiman Gary A, Willsey A Jeremy, Dietrich Andrea, Davis Lea K, Crowley James J, Mathews Carol A, Scharf Jeremiah M, Georgitsi Marianthi, Hoekstra Pieter J, Paschou Peristera
Abstract excerpt
BACKGROUND: Tourette syndrome (TS) is a childhood-onset neurodevelopmental disorder of complex genetic architecture and is characterized by multiple motor tics and at least one vocal tic persisting for more than 1 year. METHODS: We performed a genome-wide meta-analysis integrating a novel TS cohort with previously published data, resulting in a sample size of 6133 individuals with TS and 13,565 ancestry-matched...
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