Article
A genome-wide association study identifies a gene network associated with paranoid schizophrenia and antipsychotics-induced tardive dyskinesia.
Progress in neuro-psychopharmacology & biological psychiatry - 8 Mar 2021
Levchenko Anastasia, Kanapin Alexander, Samsonova Anastasia, Fedorenko Olga Yu, Kornetova Elena G, Nurgaliev Timur, Mazo Galina E, Semke Arkadiy V, Kibitov Alexander O, Bokhan Nikolay A, Gainetdinov Raul R, Ivanova Svetlana A
Abstract excerpt
In the present study we conducted a genome-wide association study (GWAS) in a cohort of 505 patients with paranoid schizophrenia (SCZ), of which 95 had tardive dyskinesia (TD), and 503 healthy controls. Using data generated by the PsychENCODE Consortium (PEC) and other bioinformatic databases, we revealed a gene network, implicated in neurodevelopment and brain function, associated with both these disorders....
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