Article

Genetic Evidence for a Novel Glutamatergic Augmentation in Treatment-Resistant OCD: CREB1 as a Key Driver of Impaired Plasticity

2025-12-24

Abstract excerpt

<h4>Background: </h4> A large proportion of people with obsessive–compulsive disorder (OCD) – roughly 40–60 % even after carefully optimised treatment – do not improve enough with selective serotonin re-uptake inhibitors (SSRIs). Small naturalistic series have suggested that the Cheung Glutamatergic Regimen (CGR), an inexpensive oral combination of dextromethorphan, fluoxetine and piracetam, can ease symptoms quic...

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Literature Corpus work: c8d22205-d3f1-51fb-b796-f27ae71b3632
DOI: 10.20944/preprints202512.2104.v1

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