Article

Integrating GWAS meta-analysis with human brain cell mapping implicates the amygdala and the midbrain in the pathogenesis of tinnitus

2025-12-01

Abstract excerpt

Tinnitus is a distressing condition affecting millions of people worldwide, yet treatment options remain very limited. Molecular evidence on the cellular origins of tinnitus in humans is lacking. Here, we performed a genome-wide association meta-analysis of clinically diagnosed and self-reported tinnitus on 888,214 individuals (75,250 tinnitus cases and 812,964 controls) from 19 independent cohorts. We identified...

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Literature Corpus work: 2ad01cb4-b9c1-5471-a90f-02c780a5272c
DOI: 10.1101/2025.11.28.25340151

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