Article

<i>In vivo</i> nuclear envelope adaptation during cell migration across confining embryonic tissue environments

2025-06-06

Abstract excerpt

In physiology and in disease, cells often migrate through narrow spaces, such as leukocytes undergoing diapedesis or cancer cells during dissemination. Cultured cells under physical confinement have been shown to experience mechanical stress due to deformation of the nucleus. Nuclear deformation can lead to loss of nuclear integrity and DNA damage, and it has been proposed to underlie cancer initiation and progres...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 704a20eb-20df-5ed3-90a3-ebe0c87e675a
DOI: 10.1101/2025.06.05.658077

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>In vivo</i> nuclear envelope adaptation during cell migration across confining embryonic tissue environmentsDOI 10.1101/2025.06.05.658077Read

Cell extrusion - a novel mechanism driving neural crest cell delaminationSemantic proximity Read

A rear-engine drives adherent tissue migration <i>in vivo</i>Semantic proximity Read

Mechanical confinement governs phenotypic plasticity in melanomaSemantic proximity Read

The 3D nuclear position and compartmentalization of genes prime their response to mechano-confinementSemantic proximity Read

Mechanical confinement governs phenotypic plasticity in melanoma.Semantic proximity Read

Persistent confined migration confers permanent nuclear and functional changes in migrating cellsSemantic proximity Read

Microgroove substrates unveil topography-driven, dynamic 3D nuclear deformationsSemantic proximity Read

Organoids reveal niche-specific mechanotransduction-guided human cortical patterning and cell fate acquisitionSemantic proximity Read

Chromatin Reprogramming via Contact Guidance-Induced Nuclear Deformation Promotes Stem Cell DifferentiationSemantic proximity Read

Tissue surface mechanics constrains proliferation-driven forces to guide mammalian body axis elongationSemantic proximity Read

Lamin B1 physically regulates neuronal migration by modulating nuclear deformability in the developing cortexSemantic proximity Read

Nuclei migrate through constricted spaces using microtubule motors and actin networks in C. elegans hypodermal cellsSemantic proximity Read