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Article

A cellular hierarchy framework for understanding heterogeneity and predicting drug response in AML

2022-01-27

Abstract excerpt

The treatment landscape of AML is evolving with promising therapies entering clinical translation, yet patient responses remain heterogeneous and biomarkers for tailoring treatment are lacking. To understand how disease heterogeneity links with therapy response, we determined the leukemia cell hierarchy make-up from bulk transcriptomes of over 1000 patients through deconvolution using single-cell reference profile...

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Literature Corpus work
ff400490-15c5-5d6f-bf4f-4401c57dffe3
DOI
10.1101/2022.01.25.476266
Open publication

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A cellular hierarchy framework for understanding heterogeneity and predicting drug response in AMLDOI 10.1101/2022.01.25.476266
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