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A transcriptomic based deconvolution framework for assessing differentiation stages and drug responses of AML

18 May 2024

Abstract excerpt

The diagnostic spectrum for AML patients is increasingly based on genetic abnormalities due to their prognostic and predictive value. However, information on the AML blast phenotype regarding their maturational arrest has started to regain importance due to its predictive power for drug responses. Here, we deconvolute 1350 bulk RNA-seq samples from five independent AML cohorts on a single-cell healthy BM...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38762545
DOI: 10.1038/s41698-024-00596-9

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