Article

Integrated decoding hematopoiesis and leukemogenesis at single-cell resolution and its clinical implication

2020-02-23

Abstract excerpt

Integrated analyses of hematopoiesis and leukemogenesis could provide new biological and clinical insights 1,2 . Here we constructed a comprehensive cell atlas using ∼100,000 single cell transcriptomes of bone marrow mononuclear cells and its subsets from 5 healthy samples and 13 leukemia samples. Trajectory analysis showed hematopoietic stem cells continuously differentiated through tree-like structure into 7 li...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a073802e-d3e2-5242-9f86-321e86a33bc8
DOI: 10.1101/2020.02.21.960401

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated decoding hematopoiesis and leukemogenesis at single-cell resolution and its clinical implicationDOI 10.1101/2020.02.21.960401Read

Integrated decoding hematopoiesis and leukemogenesis using single-cell sequencing and its medical implicationSemantic proximity Read

Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML DifferentiationSemantic proximity Read

Decoding leukemia at the single-cell level: clonal architecture, classification, microenvironment, and drug resistanceSemantic proximity Read

A cellular hierarchy framework for understanding heterogeneity and predicting drug response in AMLSemantic proximity Read

Plasticity and Dynamics of Hematopoietic Cells within Bone Marrow Microenvironment in LeukemiaSemantic proximity Read

Identification of leukemia-enriched signature through the development of a comprehensive pediatric single-cell atlasSemantic proximity Read

Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemiaSemantic proximity Read

Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AMLSemantic proximity Read

Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemiaSemantic proximity Read

Differentiation hierarchy in adult B cell acute lymphoblastic leukemia at clonal resolutionSemantic proximity Read

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.Semantic proximity Read

Application and research progress of single cell sequencing technology in leukemiaSemantic proximity Read