Article

Population genetic models of GERP scores suggest pervasive turnover of constrained sites across mammalian evolution

2019-11-09

Abstract excerpt

Comparative genomic approaches have been used to identify sites where mutations are under purifying selection and of functional consequence by searching for sequences that are conserved across distantly related species. However, the performance of these approaches has not been rigorously evaluated under population genetic models. Further, short-lived functional elements may not leave a footprint of sequence conser...

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Literature Corpus work: ff2d861f-3383-5396-9c97-ef5b12ce4b37
DOI: 10.1101/836858

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