Article

The landscape of fitness effects of putatively functional noncoding mutations in humans

2025-05-14

Abstract excerpt

<h4>ABSTRACT</h4> While annotations of noncoding regions in the human genome are increasing, the fitness effects of mutations in these regions remain unclear. Here, we leverage these functional genomic annotations and human polymorphism data to infer the distributions of fitness effects of new noncoding mutations in humans. Our novel approach controls for mutation rate variation and linked selection along the gen...

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Literature Corpus work: 33080892-3988-55a3-8e35-6fdf57a57b7f
DOI: 10.1101/2025.05.14.654124

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