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Article

Population genetic models of GERP scores suggest pervasive turnover of constrained sites across mammalian evolution.

PLoS genetics - 1 May 2020

Huber Christian D, Kim Bernard Y, Lohmueller Kirk E

Abstract excerpt

Comparative genomic approaches have been used to identify sites where mutations are under purifying selection and of functional consequence by searching for sequences that are conserved across distantly related species. However, the performance of these approaches has not been rigorously evaluated under population genetic models. Further, short-lived functional elements may not leave a footprint of sequence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32469868
DOI: 10.1371/journal.pgen.1008827
PMCID: PMC7286533

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