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Article

Simultaneous inference of selection and population growth from patterns of variation in the human genome.

Proceedings of the National Academy of Sciences of the United States of America - 31 May 2005

Williamson Scott H, Hernandez Ryan, Fledel-Alon Adi, Zhu Lan, Nielsen Rasmus, Bustamante Carlos D

Abstract excerpt

Natural selection and demographic forces can have similar effects on patterns of DNA polymorphism. Therefore, to infer selection from samples of DNA sequences, one must simultaneously account for demographic effects. Here we take a model-based approach to this problem by developing predictions for patterns of polymorphism in the presence of both population size change and natural selection. If data are available...

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Identifiers

PMID: 15905331
DOI: 10.1073/pnas.0502300102
PMCID: PMC1142382

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