Article

Pervasive cryptic selection in the human noncoding genome

2026-06-10

Abstract excerpt

<h4>ABSTRACT</h4> The prevailing dogma in evolutionary genetics holds that mutations within sequences that are conserved across a phylogeny are deleterious in those species, and mutations outside are neutrally evolving. Indeed, such comparative genomic approaches have estimated that mutations in approximately 5% of the human genome experience negative selection. However, sites that have biological function in cer...

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Literature Corpus work: 813589a2-ef4f-5e74-9bd0-b913f05ca5d9
DOI: 10.64898/2026.06.09.731256

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