Article
The Role of Phylogenetically Conserved Elements in Shaping Patterns of Human Genomic Diversity.
Molecular biology and evolution - 1 Sept 2018
Woerner August E, Veeramah Krishna R, Watkins Joseph C, Hammer Michael F
Abstract excerpt
Evolutionary genetic studies have shown a positive correlation between levels of nucleotide diversity and either rates of recombination or genetic distance to genes. Both positive-directional and purifying selection have been offered as the source of these correlations via genetic hitchhiking and background selection, respectively. Phylogenetically conserved elements (CEs) are short (∼100 bp), widely distributed...
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