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Article

Small fitness effect of mutations in highly conserved non-coding regions.

Human molecular genetics - 1 Aug 2005

Kryukov Gregory V, Schmidt Steffen, Sunyaev Shamil

Abstract excerpt

Comparison of human and mouse genomes has revealed that many non-coding regions have levels of sequence conservation similar to protein-coding genes. These regions have attracted a lot of attention as potentially functional genomic sequences. However, little is known about the effect mutations in these conserved non-coding regions have on fitness and how many of them are present in the human genome as deleterious...

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PMID: 15994173
DOI: 10.1093/hmg/ddi226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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