Article
Trade-offs in detecting evolutionarily constrained sequence by comparative genomics.
Annual review of genomics and human genetics - 1 Jan 2005
Stone Eric A, Cooper Gregory M, Sidow Arend
Abstract excerpt
As whole-genome sequencing efforts extend beyond more traditional model organisms to include a deep diversity of species, comparative genomic analyses will be further empowered to reveal insights into the human genome and its evolution. The discovery and annotation of functional genomic elements is a necessary step toward a detailed understanding of our biology, and sequence comparisons have proven to be an...
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