Article

Tumorigenicity of Ascites-Derived Tumor Cells: Insights Into the Molecular Mechanisms of Ovarian Cancer Progression and Therapy Resistance

2020-12-02

Abstract excerpt

<h4>Background: </h4> Ovarian cancer (OvCa) cells disseminate primarily intraperitoneally. Here, detached tumor cell aggregates (spheroids) from the primary tumor are generally regarded as “metastatic units”, which exhibit a survival benefit, probably due to the protective microenvironment and their unique molecular characteristics. Hence, current therapeutic concepts such as classical chemotherapy are not suffici...

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Literature Corpus work: ff16a827-7618-5782-8a06-9eea26c47fb9
DOI: 10.21203/rs.3.rs-117698/v1

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