Article

Tumoroid model recreates clinically relevant phenotypes of high grade serous ovarian cancer (HGSC) cells, carcinoma associated fibroblasts, and macrophages

2025-06-19

Abstract excerpt

<title>Abstract</title> <p>Ovarian cancer, the gynecological malignancy with the lowest survival rate, is significantly influenced by the tumor microenvironment. The mesenchymal subtype of high-grade serous carcinoma (HGSC) shows poor outcomes due to high stromal and low immune response. Single-cell RNA sequencing (scRNA-seq) of HGSC metastatic ascites has identified carcinoma-associated fibroblasts (CAFs), macro...

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Literature Corpus work: 699a8200-77c8-5631-a298-a1404a3c649c
DOI: 10.21203/rs.3.rs-6614892/v1

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