Article

The lipid kinase PI3Kα is required for the cohesion and survival of cancer cells disseminated in serous cavities

2019-09-23

Abstract excerpt

<h4> A bstract </h4> Breast, ovarian, digestive and lung adenocarcinomas are often associated with the accumulation of malignant cells in serous cavities. As PI3K is one of the most mutated pathways in cancer, we investigated the importance of oncogenic PI3Kα in this process. We analyzed tumor cell organization in ascites from carcinomas at diagnosis. In some malignant ascites, tumor cells grew as adhesive cohe...

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Literature Corpus work: d86ebd8e-94a3-5d45-94e5-e3cf21a47bf0
DOI: 10.1101/777649

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