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Article

Ascites-Driven Modulation of Cell Phenotypes and Proteomes: Implications for Cancer Progression

2026-02-15

Abstract excerpt

<h4>Background</h4> More than 90% of advanced ovarian cancer patients develop malignant ascites, which describes a buildup of fluid in the peritoneal cavity caused by increased vascular permeability and obstructed lymphatic drainage. Malignant ascites contains spheroidal tumor cell clusters that contain stromal cells, cancer-associated fibroblasts, and blood cells. These spheroids promote peritoneal metastasis an...

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Literature Corpus work
296cd55f-d3e0-50ad-bb65-34c77cdad5e1
DOI
10.64898/2026.02.12.705674
Open publication

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