Article

Organoid Models Established from Primary Tumors and Patient-Derived Xenograft Tumors Reflect Platinum Sensitivity of Ovarian Cancer Patients

2024-07-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Ovarian cancer (OC) remains the deadliest gynecological cancer, primarily due to late-stage diagnosis and high rates of chemotherapy resistance and recurrence. Lack of representative preclinical models complicate the challenges of discovering effective therapies, especially for platinum-resistant OC. Patient-derived xenograft (PDX) models maintain the genetic characteristics...

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Literature Corpus work: 503af957-9e21-5a76-a615-7588f3de1284
DOI: 10.1101/2024.06.28.601283

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