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Article

Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease.

Molecular psychiatry - 1 Jul 2023

Lake Julie, Warly Solsberg Caroline, Kim Jonggeol Jeffrey, Acosta-Uribe Juliana, Makarious Mary B, Li Zizheng, Levine Kristin, Heutink Peter, Alvarado Chelsea X, Vitale Dan, Kang Sarang, Gim Jungsoo, Lee Kun Ho, Pina-Escudero Stefanie D, Ferrucci Luigi, Singleton Andrew B, Blauwendraat Cornelis, Nalls Mike A, Yokoyama Jennifer S, Leonard Hampton L

Abstract excerpt

Genome-wide association studies (GWAS) of Alzheimer's disease are predominantly carried out in European ancestry individuals despite the known variation in genetic architecture and disease prevalence across global populations. We leveraged published GWAS summary statistics from European, East Asian, and African American populations, and an additional GWAS from a Caribbean Hispanic population using previously...

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Identifiers

PMID: 37198259
DOI: 10.1038/s41380-023-02089-w
PMCID: PMC10615750

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