Article

Electrocorticographic and Astrocytic Signatures of Stearoyl-CoA Desaturase Inhibition in the Triple Transgenic Mouse Model of Alzheimer’s Disease

2024-03-05

Abstract excerpt

<h4>ABSTRACT</h4> The symptomatology of Alzheimer’s disease (AD) includes cognitive deficits and sleep disturbances. Recent findings suggest the involvement of dysfunctions in lipid metabolism, such as oleic acid build-up, in the brain of AD patients and animal models. In addition, the inhibition of stearoyl-CoA desaturase (SCD), a lipid-converting enzyme, was shown to restore memory in triple transgenic (3xTg)-A...

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Literature Corpus work: feda4412-a83e-5442-afa2-8a3becb01e56
DOI: 10.1101/2024.03.01.582986

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