APOE4 expression is associated with impaired autophagy and mitophagy in astrocytes

Abstract excerpt

Among the risk factors for late onset sporadic Alzheimer’s disease (AD) is the expression of ε4 allele of apolipoprotein E (APOE4) gene (Mahley et al., 2006). Elevated amyloid processing and reduced degradation of Aβ, which lead to Aβ plaque deposition, are evident in APOE4-positive AD patients and mice (Mahley et al., 2006). These features correlate with neuronal cell loss. Impaired mitochondrial activity and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alzheimer's disease research and treatments
• Share to Autophagy in Disease and Therapy
• Share to Parkinson's Disease Mechanisms and Treatments