Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ascorbate insufficiency disrupts glutamatergic signaling and alters electroencephalogram phenotypes in a mouse model of Alzheimer's disease.

Neurobiology of disease - 1 Sept 2024

Buchanan Rebecca A, Wang Yuhan, May James M, Harrison Fiona E

Abstract excerpt

Clinical studies have reported that increased epileptiform and subclinical epileptiform activity can be detected in many patients with an Alzheimer's disease (AD) diagnosis using electroencephalogram (EEG) and this may correlate with poorer cognition. Ascorbate may have a specific role as a neuromodulator in AD as it is released concomitantly with glutamate reuptake following excitatory neurotransmission....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Ascorbic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Electroencephalography

Share to Glutamic Acid

Share to Mice, Transgenic

Share to Signal Transduction

Source

Identifiers

PMID: 39004234
DOI: 10.1016/j.nbd.2024.106602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ascorbate insufficiency disrupts glutamatergic signaling and alters electroencephalogram phenotypes in a mouse model of Alzheimer's disease.PMID 39004234Read ↗

Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Ascorbate deficiency decreases dopamine release in gulo-/- and APP/PSEN1 mice.Semantic proximity Read ↗

Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate.Semantic proximity Read ↗

Glial cells are involved in Day–Night protein dysregulation in the hippocampus of a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.Semantic proximity Read ↗

Ketogenic diet or BHB improves epileptiform spikes, memory, survival in Alzheimer’s modelSemantic proximity Read ↗

Electrocorticographic and Astrocytic Signatures of Stearoyl-CoA Desaturase Inhibition in the Triple Transgenic Mouse Model of Alzheimer’s DiseaseSemantic proximity Read ↗

Impaired neuromodulator crosstalk delays vigilance-dependent astroglia Ca <sup>2+</sup> activation in mouse models of Alzheimer’s diseaseSemantic proximity Read ↗

Up-regulation of GLT1 reverses the deficit in cortically evoked striatal ascorbate efflux in the R6/2 mouse model of Huntington's disease.Semantic proximity Read ↗

High Frequency Oscillations (>250Hz) Outnumber Interictal Spikes in Preclinical Studies of Alzheimer’s DiseaseSemantic proximity Read ↗

Natural age-related sleep-wake alterations onset prematurely in the Tg2576 mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.