Back to search

Article

Central inhibition of Stearoyl-CoA Desaturase has minimal effects on the peripheral metabolic symptoms of the 3xTg Alzheimer’s disease mouse model

2023-08-03

Abstract excerpt

Evidence from genetic and epidemiological studies point to lipid metabolism defects in both the brain and periphery being at the core of Alzheimer’s disease (AD) pathogenesis. Previously, we reported that central inhibition of the rate-limiting enzyme in monounsaturated fatty acid synthesis, Stearoyl-CoA Desaturase (SCD), improves brain structure and function in the 3xTg mouse model of AD (3xTg-AD). Here, we teste...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
794f4f96-3f0f-57c7-849f-c6362faac852
DOI
10.1101/2023.08.01.551291
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Central inhibition of Stearoyl-CoA Desaturase has minimal effects on the peripheral metabolic symptoms of the 3xTg Alzheimer’s disease mouse modelDOI 10.1101/2023.08.01.551291
Role of sex and high fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer’s diseaseSemantic proximity
Ketogenic interventions restore cognition and modulate peripheral metabolic dysfunctions in Alzheimer’s disease mouse modelsSemantic proximity
Electrocorticographic and Astrocytic Signatures of Stearoyl-CoA Desaturase Inhibition in the Triple Transgenic Mouse Model of Alzheimer’s DiseaseSemantic proximity
Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimer’s disease in 3xTg miceSemantic proximity
Young APPKI <sup>NL-G-F/NL-G-F</sup> mice display high-fat diet-induced metabolic disturbances and specific disorders associated with brain energy homeostasisSemantic proximity
Beyond Symptom Management: FAAH Inhibition as a Path to Mitigate Alzheimer’s Disease Progression in Mouse Models of AmyloidosisSemantic proximity
Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APP Swe Alzheimer’s Disease Mouse ModelSemantic proximity
Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease.Semantic proximity
The 3xTg-AD Mouse Model of Alzheimer's Disease Exhibits Lifelong Reductions in Circulating Choline Despite Adequate Dietary Intake, With Sex-Specific Neuropathological and Behavioral Phenotypes.Semantic proximity
Apolipoprotein E Induces Lipid Accumulation Through Dgat2 That Is Prevented with Time-Restricted Feeding in Drosophila.Semantic proximity
Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology.Semantic proximity
Examining Alzheimer's Disease modifiable risk factors: Impact of physical activity and diet on neuroanatomy and behaviour in mouse modelsSemantic proximity
Select a neighboring publication to make it the new centre.