Neural HO-1/sterol interactions in vivo: implications for Alzheimer's disease.

doi:10.1016/j.neuroscience.2014.09.001

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Article

Neural HO-1/sterol interactions in vivo: implications for Alzheimer's disease.

Neuroscience - 7 Nov 2014

Hascalovici J R, Song W, Liberman A, Vaya J, Khatib S, Holcroft C, Laferla F, Schipper H M

Abstract excerpt

BACKGROUND: Up-regulation of heme oxygenase-1 (HO-1) and altered cholesterol (CH) metabolism are characteristic of Alzheimer-diseased (AD) neural tissues. We previously provided evidence of significant HO-1/sterol interactions in vitro (cultured rat astroglia) and in post-mortem human AD brain (Religious Orders Study). METHODS: The current experiments were designed to further delineate these interactions in vivo...

Topics

Aging
Alzheimer Disease
Amyloid beta-Protein Precursor
Animals
Astrocytes
Brain
Glial Fibrillary Acidic Protein
HEK293 Cells
Heme Oxygenase-1
Homeostasis
Humans
Membrane Proteins
Mice, Transgenic
Mutation
Nerve Tissue Proteins
Oxidation-Reduction
Rats
Sterols

Source

Open in PubMed

Identifiers

PMID: 25218961
DOI: 10.1016/j.neuroscience.2014.09.001

Genes

GFAP
HMOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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