Article

Combined deletion of cytosolic 5’-nucleotidases IA and II lowers glycemia by improving skeletal muscle insulin action and by lowering hepatic glucose production

2025-01-13

Abstract excerpt

<h4>ABSTRACT</h4> Obesity and type 2 diabetes (T2D)-linked hyperglycemia, along with their associated complications, have reached pandemic proportions, becoming a major public health issue. Genetic deletion or pharmacological inhibition of purine nucleotide-metabolizing enzymes has emerged as a potential strategy for treating diseases. We previously showed that cytosolic 5’-nucleotidase II (NT5C2)-deficient mice...

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Literature Corpus work: fed7760e-62ba-5f18-94c9-46de7a9332bb
DOI: 10.1101/2025.01.09.632106

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Combined deletion of cytosolic 5’-nucleotidases IA and II lowers glycemia by improving skeletal muscle insulin action and by lowering hepatic glucose productionDOI 10.1101/2025.01.09.632106Read

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