Article

ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance

2026-04-14

Abstract excerpt

<h4>ABSTRACT</h4> The ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) has long been linked with metabolic diseases, with the common ENPP1 K173Q (historically K121Q) variant conferring increased risk for type 2 diabetes (T2D). However, the mechanistic basis of this association has remained unclear. Here, we demonstrate that the K173Q variant has decreased cGAMP hydrolysis activity, suggesting that this...

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Identifiers and source

Literature Corpus work: e2b125cc-a77f-5b01-ad76-214d04d5ee51
DOI: 10.64898/2026.04.12.718013

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