Article

Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycemic control

2025-10-02

Abstract excerpt

Metformin is a therapeutically versatile biguanide drug primarily prescribed for type II diabetes. Despite its extensive use, the mechanisms underlying many of its clinical effects, including attenuated postprandial glucose excursions, elevated intestinal glucose uptake, and increased production of lactate, Lac-Phe and GDF15, remain unclear. Here, we map these and other clinical effects of metformin to intestine-s...

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Literature Corpus work: c4c82571-faa3-5ca0-8959-929e180798b4
DOI: 10.1101/2025.10.02.678294

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