Article

Diet-induced loss of adipose Hexokinase 2 triggers hyperglycemia

2019-12-28

Abstract excerpt

Chronically high blood glucose (hyperglycemia) leads to diabetes, fatty liver disease, and cardiovascular disease. Obesity is a major risk factor for hyperglycemia, but the underlying mechanism is unknown. Here we show that a high fat diet (HFD) in mice causes early loss of expression of the glycolytic enzyme Hexokinase 2 (HK2) specifically in adipose tissue. Adipose-specific knockout of Hk2 caused enhanced gluco...

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Literature Corpus work: 2cd71145-ffe9-54e3-ae24-6c1b9cf8f116
DOI: 10.1101/2019.12.28.887794

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