Article

Compromised chronic efficacy of a Glucokinase Activator AZD1656 in mouse models for common human <i>GCKR</i> variants

2024-07-24

Abstract excerpt

<h4>ABSTRACT</h4> Glucokinase activators (GKAs) have been developed as blood glucose lowering drugs for type 2 diabetes. Despite good short-term efficacy, several GKAs showed a decline in efficacy chronically during clinical trials. The underlying mechanisms remain incompletely understood. We tested the hypothesis that deficiency in the liver glucokinase regulatory protein (GKRP) as occurs with common human GCKR...

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Literature Corpus work: a30aeeef-7511-55f5-9079-34cc19f5c83b
DOI: 10.1101/2024.07.24.604910

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