Article

Vitamin B2 enables peroxisome proliferator-activated receptor α regulation of fasting glucose availability

2022-10-18

Abstract excerpt

Flavin adenine dinucleotide (FAD) interacts with flavoproteins to mediate oxidation-reduction reactions required for cellular energy demands. Not surprisingly, mutations that alter FAD binding to flavoproteins cause rare inborn errors of metabolism (IEMs) that disrupt liver function and render fasting intolerance, hepatic steatosis, and lipodystrophy. In our study, depleting FAD pools in mice with a vitamin B2 def...

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Literature Corpus work: e6ab870f-7432-5881-9374-fa7464f218e3
DOI: 10.1101/2022.10.16.512439

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