Article

Phenylalanine Impairs Insulin Signaling and Inhibits Glucose Uptake by Modifying IRβ

2021-05-17

Abstract excerpt

<title>Abstract</title> <p>Although elevated circulating amino acids are associated with the onset of type 2 diabetes (T2D), how amino acids act on cell insulin signaling and glucose uptake remains unclear. Herein, we report that phenylalanine modifies insulin receptor beta (IRβ) and inactivates insulin signaling and glucose uptake. Mice fed phenylalanine-rich chow or overexpressing human phenylalanyl-tRNA synthe...

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Literature Corpus work: 834db594-a4ad-55a0-8eea-ede10a78c959
DOI: 10.21203/rs.3.rs-483980/v1

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