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Article

The tumor therapy landscape of synthetic lethality.

Nature communications - 24 Feb 2021

Zhang Biyu, Tang Chen, Yao Yanli, Chen Xiaohan, Zhou Chi, Wei Zhiting, Xing Feiyang, Chen Lan, Cai Xiang, Zhang Zhiyuan, Sun Shuyang, Liu Qi

Abstract excerpt

Synthetic lethality is emerging as an important cancer therapeutic paradigm, while the comprehensive selective treatment opportunities for various tumors have not yet been explored. We develop the Synthetic Lethality Knowledge Graph (SLKG), presenting the tumor therapy landscape of synthetic lethality (SL) and synthetic dosage lethality (SDL). SLKG integrates the large-scale entity of different tumors, drugs and...

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Identifiers

PMID: 33627666
DOI: 10.1038/s41467-021-21544-2
PMCID: PMC7904840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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