Article

Beyond synthetic lethality in large-scale metabolic and regulatory network models via genetic minimal intervention sets

2025-11-10

Abstract excerpt

<h4>Motivation</h4> The integration of genome-scale metabolic and regulatory networks has received significant interest in the field of Cancer Systems Biology. However, the identification of lethal genetic interventions in these integrated models remains a substantially challenge due to the combinatorial explosion of potential solutions. To address this issue, we previously developed the genetic Minimal Cut Set (...

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Literature Corpus work: f0d33961-7bdf-508a-8cd3-1aae411cec22
DOI: 10.1101/2025.11.07.687323

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