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Article

Review and meta-analysis of the genetic Minimal Cut Set approach for gene essentiality prediction in cancer metabolism.

Briefings in bioinformatics - 27 Mar 2024

Olaverri-Mendizabal Danel, Valcárcel Luis V, Barrena Naroa, Rodríguez Carlos J, Planes Francisco J

Abstract excerpt

Cancer metabolism is a marvellously complex topic, in part, due to the reprogramming of its pathways to self-sustain the malignant phenotype in the disease, to the detriment of its healthy counterpart. Understanding these adjustments can provide novel targeted therapies that could disrupt and impair proliferation of cancerous cells. For this very purpose, genome-scale metabolic models (GEMs) have been developed,...

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PMID: 38546323
DOI: 10.1093/bib/bbae115
PMCID: PMC10976907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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